RESEARCH CHEMICALS
Romiplostim Nplate 250 mcg – 500 mcg
Romiplostim Nplate 250 mcg – 500 mcg
Price range:
€381.00 – €752.00
Romiplostim Nplate is an antihemorrhagic agent. This member of the class of thrombopoietin (TPO) mimetics is an Fc-peptide fusion protein (peptibody) that activates intracellular transcriptional pathways and leads to increased platelet production via the TPO receptor (also known as cMpl), a mechanism analogous to endogenous TPO.
Nplate is specifically indicated for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura (ITP) who have had an inadequate response to corticosteroids, immunoglobulins or splenectomy.
Nplate is supplied as a sterile solution (250 µg and 500 µg) for subcutaneous administration. Nplate must be reconstituted with preservative-free sterile water for injections. The recommended starting dose of the drug is 1 mcg/kg once weekly, based on actual body weight, as a subcutaneous injection.
Dosage adjustments
To reduce the risk of bleeding, use actual body weight at the start of therapy and then adjust the weekly Nplate dose in increments of 1 µg/kg until the patient achieves a platelet count of at least 50 x 109/L; not to exceed a maximum weekly dose of 10 mcg/kg.
Set as follows:
If the platelet count is < 50 x 109/L, increase the dose by 1 μg/kg.
If the platelet count is > 200 x 109/L for 2 consecutive weeks, reduce the dose by 1 μg/kg.
If the platelet count is > 400 x 109/L, do not dose. Continue to assess the platelet count weekly. After the platelet count falls to < 200 x 109/L, restart Nplate at a dose reduced by 1 microgram/kg.
If platelet counts do not increase after 4 weeks at the maximum weekly dose of 10 µg/kg, Nplate should be discontinued.
Side effects
Side effects associated with the use of Nplate may include, but are not limited to:
• Headache
• Arthralgia
• Dizziness
• Insomnia
• Myalgia
• Pain in extremities
• Abdominal pain
• Shoulder pain
• Dyspepsia
• Paraesthesia
Mechanism of action.
Romiplostim Nplate is an antihemorrhagic agent. This member of the class of thrombopoietin (TPO) mimetics is an Fc-peptide fusion protein (peptibody) that activates intracellular transcriptional pathways and leads to increased platelet production via the TPO receptor (also known as cMpl), a mechanism analogous to endogenous TPO.
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